We’ve all seen the T-shirts and knick-knack signs emblazoned with the alliterative slogan “coffee ’till cocktails.” It’s not just a cute saying—it’s a reality for many who bounce back and forth between the stimulating effects of coffee and the sedative effects of alcohol. Though it may feel like these beverages are a lifeline for getting you through the challenges of your day, yo-yoing between caffeine and alcohol can come with some downsides.